History

NeoLek - Integrated Laboratory of Experimental Oncology and Innovative Technologies derives from the Department of Experimental Oncology of Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences in Wroclaw. Since 1969 in this Department, Prof. Czesław Radzikowski’s science team has been conducting research on potential anticancer substances, resulting  in significant achievements in science.

  • Selection of  preparations with potential anticancer activity, including: the introduction of the original drug (Ledakrin) and  recommending  to the preparations  of the group and bromine  derivatives of, ifosfamide and imidazo acridinone, synthesized in the Department of Pharmaceutical Technology and Biochemistry,  Gdańsk University of Technology,  an international program of preclinical studies. Preparation of symbol CBM-4A (racemic chlorobromofosfamide)  has qualified  for the phase I/II clinical trials by the committee acting  under the Cancer Research Campaign in in the UK;
  • Developing models of transplantable  mouse tumors, the organization of the Centre Breeding Mice Bank Institute and Cancer Line of animal and human;
  • Identification of   the antigen ML (mammary leukaemia) on the surface of  leukemic cells;  demonstrating quantitative differences in the expression of antigens H-2  complex antigens and leukaemia, indicating on significant correlation between  the expression of tumour antigens (TAA) and the loss of some  of the specificity of the H-2 complex;  to demonstrate differences in  the expression of surface antigens (TF, Tn, sjaloLea) and profile glycosylation  of glycoproteins and glycolipids  associated with cancer malignant phenotype; introduction of a human tumor xenotransplantation model  to athymic mice;
  • Participation in preclinical  studies in the field of  cancer chemotherapy in  the government programme "Combating Cancer", coordinated by  the Memorial Cancer Centre Institute – Maria Sklodowska - Curie in Warsaw and in multicentre studies "Synthesis, preclinical  studies and the development of production technology and drug compounds for anticancer activity”;

One of the  initiators of the creation of NeoLek Laboratory was the first head of the Department of Experimental Oncology – Prof. Adam Opolski (1955-2005). Two laboratories of this department became NeoLek’s backstage – the Laboratory of Experimental Anti-cancer Therapy (study of biological activity of preparations in vitro and in vivoand the Laboratory of Biomedical Chemistry (at the levels of drugs and their metabolites, biotransformation of drugs and innovative technologies).

 

DAVIE, Fla. (AP) Jay Cutler has decided to postpone retirement for the chance to be Ryan Tannehill's replacement.Cutler agreed to terms Sunday on a contract with the Miami Dolphins, a person familiar with the situation said. The person confirmed the agreement Ryan Tannehill Jerseys to The Associated Press on condition of anonymity because the Dolphins weren't expected to announce the deal until Cutler signed the $10 million, one-year deal.Cutler will compete with Matt Moore for Cameron Wake Jerseys a starting job while Tannehill remains out with a left knee injury that could sideline him for the entire season.Dolphins coach Adam Gase was offensive coordinator for the Chicago Bears when Cutler had a career-best quarterback rating with them in 2015. Gase joined Miami in 2016, and Cutler parted with Chicago in March after eight seasons.Cutler, 34, drew little interest in the spring as a free agent, perhaps partly because Jarvis Landry Jerseys of his prickly personality and tendency for turnovers."I guess I know a different guy than what everybody else portrays," Gase said in May, when Cutler was hired by Fox as an analyst to work on its No. 2 NFL team.Tannehill, who missed the final four games of last season with two sprained ligaments in his knee, reinjured it a week into training camp Thursday. The damage is similar last year's injury, a personal familiar with Jay Ajayi Jerseys the diagnosis said, which has left the Dolphins consulting with specialists to determine whether surgery is the best option for Tannehill.He's expected to be sidelined a minimum of six weeks, but the deal with Cutler signals the Dolphins anticipate Tannehill will need a lengthier recovery.Cutler is 68-71 as a starter with a career quarterback rating of 85.7, 208 touchdown passes and 146 interceptions. Ndamukong Suh Jerseys Several NFL starting QBs are older, including New England's Tom Brady, who just turned 40.Moore turns 33 next week and has 28 starts in 10 seasons.